Abstract: Medical robots played an increasingly important role in the recent decade. Safety is one of the key issues in designing a medical robot but traditional safety methods for industrial robot are not enough for medical robots. In the first case, a common method to prevent people from interacting with the robot is the isolation of the instrument using passive devices like metal fences or optical barriers. In surgical applications, the operation target is a tissue or a human organ, and the patient lies within the reach of the robot. Safety is a life-critical parameter in neurosurgical applications due to particular features of the cerebral tissues, so safety standards have to be carefully planned to limit the global operation risk. In order to improve the safety of neurosurgical robots we propose a four-step analysis: a mechanical project oriented to simplify robot movements during the operation, an intuitive interface for the surgeon to assure panic-free operations, the optimization of real time control and the implementation of fail safe principles to minimize patient’s tissue damaging. In this paper, we present the safety solutions adopted for a surgical master-slave haptic system, named LANS (Linear Actuator for Neurosurgery) developed at the Department of Innovation in Mechanics and Management of University of Padua.